Drafts

The complexity of regulation of genes provide a lot of variability in symptoms. Transporter brings T4 into cell, T3 transported into a nerve cell where it binds to nuclear receptor. Nerve cells do not have the ability to convert T4 to T3, glial cells do this converting and the nerve cells have to take up the T3 that they have converted. If T3 does not get into nerve cells, there will be severe muscular deficiencies. Cell specificity of steroids depends on the presence of a receptor: for example, there must be an estrogen receptor for a cell to be affected by the presence of estrogen. The gene that codes for TRH is relatively small, and there are five copies of it in its precursor. When cut, the intervening pieces of protein become available. TRH mRNA is more plentiful than the TRH peptides.

In this experiment we planned to find the correlation between the number of arthropods present and temperature, as we predicted that the higher the temperature would also mean a higher amount of arthropods. We went to two separate buildings on opposite sides of the Morrill complex of buildings to compare the temperatures and find how many arthropods would be present on the windowsills. We decided to take five different points in each building of Morrill III and Morrill IV. In Morrill III, we observed window sills in rooms 203, 204, 302, 304, and 404 to look for arthropods, and recorded the data of a two week span. In Morrill IV, we observed window sills on floors 4, 3 and the stairwell from floor 3 to floor 2 and floor 2 to floor 1, we also recorded the data for a two week span. The trend that is shown in our graphs shows that as the temperatures are raised the number of arthropods present also rises. Although there are fluctuations in the number or arthropods present which we believe to be contributed to the fact that the temperature fluctuates throughout the week and day.

There have been various attempts to improve traceability and safety in the supply chain process such as Hazard Analysis and Critical Control Points (HACCP).  However, any attempts to improve safety and traceability do not address the underlying issue; a lack of infrastructure for handling and processing records. Whole Foods lists selling the highest quality products available as the top core value and mentions that they “maintain the strictest quality standards in the industry.” Incorporating new technology to the supply chain process is a necessary change in the way our food is handled. Whole Foods has the opportunity to be one of the first of many supermarkets to make substantial changes. As a partner of Amazon, there is potential for their company to also to greatly benefit from this technology and its applications. Pairing with Amazon, or other large technology companies such as IBM is a conducive way to accomplish this task. Not only will Whole Foods benefit, but your customers will too. It is a win-win situation, another principle Whole Foods values as described in their core values.

Blockchain is a relatively new technology and its potential impact/applications are great. Incorporating blockchain technology would hold processors more accountable for accurate details, as well as a "allow easy tracking of information regarding produce and meat with a completely new system." There are a few meat processors in Asian countries incorporating this technology in an effort to drastically improve food safety. Earlier this year, International Business Machines (IBM) has partnered with multiple food giants such as Walmart, Nestle, DOLE, Tyson and McCormick to begin testing and implementation of a new blockchain systems to guarantee safer and more traceable food. Frank Yiannas reconducted the mango experiment with a test blockchain system, and his staff was able to locate the source in 2.2 seconds, a significant improvement from the initial experiment.

The relevance of the questions posed in this study is to find another safe effective treatment for depression. This new treatment is to be used for those who have not had success from previous less invasive treatments such as therapy or drug therapy. If the treatment is proven safe and effective it can help those who are suffering from previously untreatable depression for most of their lives.

Medical anthropology is the study of disease, health-care systems, medical practices and mental illness with a cross-culture perspective. One example of medical anthropology given by the book is the work of Louis Golomb in 1985, when he researched curing practices in Thailand. The medical practitioners in this location draw on astronomy, herbs, exorcism, faith healing and massage among other methods to treat patients. What Golomb saw is that many people living there, even those who were highly educated and those who were educated in the west, used both western medicine and these traditional practices to relieve their ailments. He called this therapeutic pluralism.

The objective of the study is to see if deep brain stimulation that is common use of treatment in diseases such as Parkinson’s disease can be used to safely treat treatment-resistant depression. There were two question that were posed in this study. The first question was addressing whether or not there is an antidepressant effect associated with sham SCC DBS. The second question was whether or not SCC DBS is safe and effective in patients with treatment-resistant bipolar depression.

HA1 is mating type a with an ade mutation resulting in mutant deficit for adenine biosynthesis. HA2 is also a mating type a with an ade mutation which also makes it mutant deficit for adenine biosynthesis (1). The color of yeast strains through growth will vary depending on the type of media utilized that lack the ade gene function. To see if yeast colonies formed we used adenine biosynthesis. Adenine is known to produce a red color, so we analyzed yeast cells to see if they changed color. If they did not have the ADE gene function, then this meant they lacked the red pigment. It is known that mutations in ADE1 and ADE2 result in the accumulation of metabolic intermediate like AIR and CAIR that result in a red color. This marks the change in color of the yeast mutant cells colonies (1). YED media has all the nutrients necessary for a yeast cell to grow and thrive. This media has a tiny amount of adenine that help adenine-requiring (ade) strains. However, ade mutants are known to grow well in this particular media having a red pigment that is due to the accumulation of and intermediate in the adenine biosynthesis pathway. The MV media has the minimal number of things that are required to help in the growth of wild-type yeast cells. This media lacks adenine which means that ade mutants are not able to grow. (1)  

Saccharomyces cerevisiae, a unicellular eukaryotic fungus also known as budding yeast, has two forms in which it can be in: haploid or diploid. Haploid form exists as one of the two mating types which is MATa or MAT and when together form diploid. In haploid form they can only survive in optimal nutrient-rich surroundings. When the diploid forms are in starvation, however, they can sporulate and become haploid once more with the production of ascus which protects the four haploid spores. When nutrients supply is restored then germination of the ascus and spores will occur. If not, then the ascus will remain intact until a favorable environmental condition is meet. Diploid and haploid yeast cells have the ability to undergo budding which is essentially cell division in yeast. (1) In Saccharomyces cerevisiae, the start of meiosis is controlled and regulated by mating type and nutritional conditions. This all occurs in MATa or MAT cells in nitrogen depletion media (Kassir et al. 2003). HB1, HA0, HA1, and HA2 were the haploid strains used with each containing its own characteristics. HB1 is mating type  with an ade mutation making it mutant deficit for adenine biosynthesis. HA0 is mating type a containing no mutations and has the ability to synthesize adenine.

Genetic defects in alpha receptor have normal thyroid hormone levels. They found this by screening many people as they did not know what to look for. Cardiovascular problems are common, so this could not have been used as a screening tool for someone with alpha receptor defects. The hypathalmic-pituitary-thyroid hormone pathway is very sensitive to hormone defects. T4 is the most abundant hormone in the blood, however T3 is the biologically active form. T4 is transported actively across the cell membrane into the cytoplasm and the receptor is already bound to DNA in the un-liganded form. The symptoms of thyroid disease are variable; two people with this disease are likely to have very little symptom overlap.