The primary objective in this assignment is to obtain a diverse set of skills when composing a scientific literature piece. To learn about the aspects in writing and composing scientific writing entries. In particular, we focused on the methods section part of the composure. The methods section in a piece of scientific writing is an important aspect of an experiment because it illustrates to other prospering scientist what they carried out to obtain the results they desired. Every experimental procedure has an idea and hypothesis. Their method of proof could either fail or succeed. However, the primary objective is to be as detailed as possible so that others could replicate it and obtain similar results. A multi-panel figure was created to illustrate the plant species of our choice and it includes a detailed picture of the plant, the plant species as a whole, and a high-quality map depicting the origin of the species. For this project I choose Euphorbia pulcherrima euphorbiaceae, which is a plant found in Mexico and Guatemala.
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For this assignment the primary objective was to learn about the aspects in writing and composing scientific writing entries.The methods section is an important aspect of an experiment because it illustrates to other prospering scientist what they carried out to obtain the results they desired. Every experimental procedure has an idea and hypothesis. With this hypothesis in mind there are a variety of components that go into supporting it. Their method of proof could either fail or succeed. However, the primary objective is to be as detailed as possible so that others could replicate and obtain identical results. Throughout this project we will learn of a variety of ways to gain skills in being descriptive, experimental, and innovative. A multi-panel figure was created to illustrate the plant species of our choice and it includes a detailed picture of the plant, the plant species as a whole, and a high-quality map depicting the origin of the species.
In order to achieve an ideal picture, one must take a picture when the light is shining on the plant to portray its pigmented red color. A full picture of the species will illustrate a variety of the species. To accomplish this a few feet should be taken back from the plant to capture other species in the frame. Should be standing at an angle. In achieving a close-up photograph of the plant, an individual must get close to the species which is about six and a half inches away. This is to capture an ideal picture and draw attention to the details that this particular species contains. In the close up and full plant photographs it will contain the surrounding green color leaves that embody it. In each photo light should reflect on the plant to complete the image.
In order to evaluate our patients, progress and if our methods of treatment are working we will be performing PET scans. This will give us an image regarding the patient’s response to the treatment and whether the tumor has progressed or not. It will give us the molecular activities within the patient. This is a great way since the patient will not be harmed and it will illustrate whether we are targeting the correct pathway or of modifications will be needed. Pet scans also have the ability to measure an individual’s blood flow, glucose, and oxygen use. This will also help us see if organs surrounded the tumor are working. Overall, we will be obtaining molecular info with the use of nuclear medicine imaging.
ML385 would be another great inhibitor to use to target the trans activation of NRF2, transcription factor. This all works by ML385 finding a potential binding domain within NRF2 and in these case it will be the cap and collar or Neh1. Neh1 is also a region in which DNA binding occurs. Once it finds the potential binding domain it doesn't allow for the binding of the Nrf2-MAFG complex to ARE. MAFG is just a kind of sMaf, which are basic regions for leucine zipper type transcription factors. They act on gene regulation. This all results in a decrease in the rate of transcriptional activity. In a Keap1 mutation it will result in the levels of GSH being reduced and GSH is composed of cysteine, glutamate and glycine.
The way it's doing this is by guiding glutamine which we know is the addiction and directing it towards a pathway in which small molecules will be converted to large molecules. This will enhance purine synthesis and have an effect on pentose phosphate pathway to further the progress of cell proliferation and division. Essentially, Nrf2 when not disturbed and plays its role and regulated it helps in the removal of carcinogens. When hyperactive the malignant tumorous cells can tolerate reactive oxidative species and will avoid programmed cell death.
The Keap1-Nrf2 pathway is a regulator of providing protection to cells from harmful agents like peroxide or singlet oxygen. In this pathway, Nrf2 is bound to Keap1 and is kept it in the cytoplasm unless stressors come in which then means that they dissociate from each other. This leads to Nrf2 entering the nucleus through phosphorylation. Ubiquitination and degradation of Nrf2 occurs when bound to Keap1. Once in the nucleus Nrf2 binds to ARE (antioxidant response element) and sMaf. When there is a loss of function in Keap1, it leads to Nrf2 to continue and not be regulated. Nrf2 in malignant cells will provide an increase in chemoresistance and this will then facilitate cell growth of the tumor. When there is the overactivation of Nrf2 it is essentially affecting cell proliferation.
In image 22 there are some similarities and differences between the two multi panel figures. They had the same plants for the three labeled panels (A, B, C). The ruler is depicted in both multi-panels. However, there are some differences in the position of the ruler in the images. The type of ruler used was different and the detail of the images is different as well. Some factors that could have resulted in the differences are the specificity of how far the technological device should be in regard to the plant. Another is how detailed the image should be and what to include. In addition, in the left multi-panel one could observe that each image is a close-up to the plant and illustrates more details versus the right multi-panel figure.
An exampe of an observation and inference situation is watching somone cry and inferring they might be sad. However, the individual could be crying of excitment and joy. They could have received good news that they were so happy they shed tears. Another situation could be where they are sad and might be overwhelmed or stressed.
I went to Morrill III building and entered the greenhouse. I was walking through the greenhouse observing the variety of plant species that surrounded me. However, my attention was drawn to a particular plant species. It stood out form all other types of plant species. It was a red plant. I usually see my mom always buy this type of plant around Christmas time. It reminded me of family and unity. It had such a vibrant color and stood out to me from all the other plants. I immediately decided to choose this as my figure to illustrate to others.