A chemotherapy drug that would link with CB-839, a glutiminase inhibitor would be docetaxel. Docetaxel is known as a antimicrotubule agent. This means that it inhibits the formation of microtubules. Microtubules are highly involved in replicating and pulling apart chromosomes and sister chromatids throughout various stages of the cell cycle. Microtubules are known to be unstable. They contain a plus and minus end. The plus end is referred to as beta and the minus end as alpha. Tubulin is the building blocks of microtubules. Tubulin assembly can happen at either end of the microtubule. When outside the cell it is most favorable at the plus end and depolymerization happens on the minus end. Inhibition of the formation of microtubules will collapse and will result in cell death. Overall, the use of docetaxel with Cb-839 will be a great contribution to targeting KRAS-driven lung adenocarcinoma.
Comments
I would suggest adding
I would suggest adding another comma after 'inhibitor' in the first sentence. Consider revising this sentence 'Inhibition of the formation of microtubules will collapse and will result in cell death.' to 'Inhibition of microtubule formation will cause them to collapse and result in cell death.'
"Tubulin is the building blocks of microtubules"
This sentence seems tricky as far as pluralization goes, and I'm not exactly sure what to call a lot of tubulin, but I think it would either be "Tubulin are the building blocks..." or "Tubulin is the building block...".
Consider rewording the first
Consider rewording the first sentence. In its current state it doesn't flow well and is not specific as to what you are describing.