Effects of Chromosome Mis-segregation Conclusion PP

         Chromosome mis-segregation can lead to a number of physiological issues both in the short and long-term. The cause and effects of various chromosomal mis-segregation events and their molecular pathways are still not fully understood. Despite being shown to cause decreased cellular proliferation, aneuploidy is seen in an astounding 90% of solid tumors and 50% of blood cancers. Continued research is needed, however studies have shown that aneuploidy and CIN can both promote and inhibit tumorigenesis. A greater understanding of the role aneuploidy plays in tumorigenesis could shed light on the possible development of new cancer therapies in the future.