An inhibitor we would use to target TLR3 is (R)-2-(3-chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid (4a). This inhibitor is also referred to as compound 4a. It is an antagonist to TLR3 signaling and it inhibits the expression of downstream signaling pathways that are assisted by the TLR3/dsRNA complex. This compound is able to inhibit TLR3 signaling without affecting other types of TLRs. This illustrates it's highly selectivity characteristic. It also holds the property of being low cytotoxicity. In order to further emphasize that it directly binds to TLR3, a fluorescence anisotropy assay will be used to demonstrate that it competes with dsRNA, which is known to be involved in activating TLRs.
Comments
Comment
In the sentence "This illustrates its highly selectivity characteristic" there should not be an apostrophe in "its"
Thw first sentence doesn't
Thw first sentence doesn't make much sense, what is the inhibitor?
Instead of saying "holds the
Instead of saying "holds the property of being low cytotoxicity", maybe say "It has low cytotoxictity" as it simpler and can be said in fewer words.