In the 19th century, there was debate about the brain and how it functions. There were two different theories of how the brain worked. Camilo Golgi, best known for creating the Golgi stain, had theorized that the brain was circulatory network such as the heart and that neurons were all connected. Another scientist Santiago Ramon y Cajal believed that the brain worked via contact rather than connection. He theorized that neurites of different neurons are not continuous with each other and communicate by contact. The theory that was proposed by Ramon y Cajal would be known as the Neuron Doctrine. However, his theory was not accepted until proven much later by the electron microscope, and is now universally accepted.
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