machinery produces gametes = testes
testis histoligcal picture, seminiferous tubules, each lobule has a single one of these, connected at the end, single piece
spermatogenic wave seen at different cross-sections of these STs
picture (label testis)
immature gametes but those at the bottom are sertoli cells
req’d for sperm maturation/production
dev of speratocytes into spermatids (mature towards the middle but not functional yet)
cells in the ISF
Leydig cells, have LH-receptors to make testosterones aka leydig make test in response to LH
sertoli cell has FSH-receptors, makes inhibin then NF effect that feeds on pituitary and hypo
blood testis barrier, how do the premordial germ cells get thru it
fluid in ST is different from serum (that’s how we know it is a barrier, active transport)
primary germ cells become spermatoccytes then ...
test can be converted to 2 horomes 5 alpha DHT and
reductase does this, when it is converted into this, ir can’t be reconverted, it becomes an androgen
araamotase converts testosterone to estragen
is testosterone acting via androgen that hits the androgen receptor or estrogen that hits and estrogen receptor?
androgen receptor that mediates effects of DHT
DHT is responsible for some thing in the male
test and DHT and how the receptor works
can be converted to DHT depending on the cell
test receptor is not bound to DNA, test binds to it, dissociation of HS protein and translocated to bind to DNA and regulate transcription of genes
that is why DHT and test can produce different effects, different chromatin sites = different genes and that is how they are different and are able to tell the difference
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