Therefore having a lower recruitment of neutrophils in the lung could result in a decrease of lung metastasis with TLR3 already inhibited. This then suggest that TLR3 is also involved in promoting pre-metastatic niche creation by recruiting neutrophils to the lung [7]. When TLR3 is present in host stromal cells than chemokine production is high and this then means that neutrophils have an easy way to mobilize and be recruited which we already know are known to contain Bv8 and this will then mean that transportation of tumor cells and facilitation is increased as well [7]
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