Week 10 Draft 1

To see whether TLR3 is involved in pre-metastatic niche formation, the expression of Bv8 was studied since it is involved in promoting primary tumor cell migration and invasion to the potential metastatic site [7]. Studies concluded that TLR3 inhibited had a decrease in the expression of Bv8 which means that transportation of the tumor cells was decreased as well. It also was illustrated that a protein known as fibronectin was downregulated which means that this protein involved in binding BMDCs and tumor cells in pre-metastatic niche was inhibited [7] . It has been known that bone marrow cells bring tumor cells to different sites to form metastatic sites.