The results of the experiment included high glutamate release in synapses between
medium spiny neurons within the nucleus accumbens of the mice brains. It was the opposite in the synapses between medium spiny neurons within the dorsal striatum of the mice brains. It is shown that the mouse lacking VGLUT2 ended up without glutamate release even with dopamine stimulation in the dorsal striatum.
The weakness of this study include using mice brains instead of human brains. Just because the occurrences take place in mice brains does not mean the same results will occur with human brains. Another weakness is that they only performed dopamine stimulation in two parts of the brain and not other parts of the brain. There could be other parts besides the nucleus accumbens that has an increased ability to respond to stimuli. Given these weaknesses, the results are still valid because they are results for the nucleus accumbens in adult mice brains.
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