Dr. Rolf Karlstrom is a professor in the biology department at UMass Amherst. Since 1999, he has has performed research in his lab using the model species of the zebrafish. The research done in the lab covers many different subjects, with the overarching topic being the study of developmental neurobiology. The lab studies both larval and adult zebrafish brains to answer questions about how and why the brain forms in the way it does. The lab studies many different genes which influence the development of the brain. One of the main focuses of the lab is looking at the Hedgehog genes, specifically Sonic Hedgehog (Shh). The lab has published papers in the past detailing some of the ways Shh effects brain development, and is still today looking to answer further questions about the gene.
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