The work of F. Sanger (powerpoint presentation)

Fred Sanger received his education at Cambridge University where he later continued in research on the structure of proteins. His first major project was on the structure of Insulin. He used the Jigsaw puzzle method to break apart the molecule so that he could piece it together based off of the properties of the amino acid chemical bonds. This allowed Insulin to be sequenced for the first time and his method won him his first Nobel Prize in Chemistry. He later went on to work on sequencing DNA. There were some methods already established for this, but they were not realistic for common use due how complicated and time consuming they were. Sanger created a method that would stop the strand in replication at specific nucleotide so that when put through a gel the location of certain letters could be sequenced. This method was common place for some forty years after he published it. Sanger won his second Nobel Prize in Chemistry for this work, making him one of two people to win two Nobel Prize's in the same field.