Week 7 Draft 5

Essentially, this is performed via the TRIF and RIP1 dependent mechanisms. This involves the recruitment DD containing adaptor protein FADD through the interaction of DD. FADD through DED (death effector domain) is able to interact with procaspase-8. When activated is then believed to initiate cell death. The activation of TLR3 in lung epithelial cells is involved in promoting neutrophil recruitment in the pre-metastatic lung. Neutrophils in the tumor-bearing host can change their polarization resulting in the alteration of rather than suppressing they will be promoting tumor metastasis.