The way it's doing this is by guiding glutamine which we know is the addiction and directing it towards a pathway in which small molecules will be converted to large molecules. This will enhance purine synthesis and have an effect on pentose phosphate pathway to further the progress of cell proliferation and division. Essentially, Nrf2 when not disturbed and plays its role and regulated it helps in the removal of carcinogens. When hyperactive the malignant tumorous cells can tolerate reactive oxidative species and will avoid programmed cell death.
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