Week 10 Draft 4

BRM270 is made up of 7 distinct types of plants known as Saururus chinensis,, Aloe vera, Arnebia euchroma,Citrus unshiu Markovich, Portulaca oleracea, Scutellaria baicalensis, and P.vulgaris var. Lilacina. Studies have shown that this substance plays a role in inhibiting tumor cell proliferation [19]. Some of these extract plants are known to be involved in anti-inflammatory activity like P.vulgaris var. Lilacina [20] BRM270 has been illustrated to suppress formation of tumors and does this by negatively regulating nuclear factor-kB signaling in drug resistant cancer stem cells. A study was conducted in which lung adenocarcinoma cells migration and invasion to other areas as well as chemoresistant derivatives was inhibited by treating it with BRM270.