Neutrophils are involved in cellular mediating in damaging microorganisms. It damages cells and tissues of the host. It also contains properties involved in healing wounds and they make key contributions to recruiting and then activating and programming dendritic cells and macrophages. Then the adaptive immune system does its job and regulates the rate of neutrophils being produced in bone marrows. [10] Neutrophils have been studied to be involved in facilitating lung cancer metastasis. The main bone marrow derived cells found in the metastatic niche are known as cKIT+ and vascular endothelial growth factor receptor 1 (VEGFR1+ ) myeloid cells. Bv8 is also present in pro-metastatic neutrophils.
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