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Off switch of capases

Submitted by benjaminburk on Sun, 04/15/2018 - 20:01

Caspase-3 is a protein invloved in apotosis or programmed cell death. The protein also has a key role in overall cell development when expressed in low levels. A new research study has helped show the balance of the two pathways through biophysical, structural and computational approaches in order to demonstrate the phosphorylation of conserved sites. These results helped provide new insights into allosteric regulaton mechanisms and new opportunities for modulator developement. These new developements will help give more precise information on the cells developement and death cycle.