The purpose of this study was to investigate the differences and similarities in membrane ruffling of fibroblast cells (NIH 3T3) and melanoma cells (B16). Membrane ruffling involves the formation of newly polymerized actin filaments at the cell surface creating lamellipodia, which extend and allow the cell to actively migrate. Examining differences in quantity and frequency of ruffle formation can provide rationale for differences in roles that each cell type plays.
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