Ephrin Tyrosine Kinase Evolution

Ephrin receptor tyrosine kinases divereged from other tyrosine kinases throughout the course of evolution. The divergence came from the response to specific activation and regulatory signals that require pairing kinase catlytics and regulatory functions. The similarities between the two receptors include everything from structure, organization, function and the types of pathway they activate. Juxtamembrane and sterile a motif were both found to be linker regions to the respective kinase domain. These linker regions are responsible for increasing kinase activity and regulating the pathways functionality. These kinase proteins are responisble for everything from protein synthesis and activation to hormonal regulation and secretion.