- low Thyroid v. high Thyroid symptoms associated w/ these levels
- hypothyroidism: excothalmose, bulging eyes, 30% of patients have them
- hyperthyroidism: diagnosing these disorders is difficult b/c symptoms are not the same for everybody even tho it’s the same H
- radioimmunoassay is a way to measure thyroid hormone in you by the doctor
- measurements of thyroid hormone in blood defines thyroid diseases, can have all these symptoms but unrelated to Thyroid hormone levels is the “normal” range “normal”? how is the range measured?
- studies of populations that are the same in many ways
- exclude those w/ signs of disease
- there is a lot of variation in the population but for each individual , variation is only about 10%, they only take one measurement for you
it could be a normal value for her but it could be outside the reference age, bc of varianve of the ind
- sub-clinical TH category?
- important for pregnancy because fetus require Thyroid for development and their's don't begin to function until later on
- t4 and t3 released from T gland, but t4 comes from liver also
- t3 levels in blood aren’t indicator of T function, good indicator of t4 metabolism instead
- t4 binds to R w/ low affinity, needs to be converted to t3 to be more active
- not very soluble in water and not soluble enough in membranes that in can cross membrane by itself
-specific transporter that actively transports TH across membrane across the cell
- genetic defect in this transporter = development of very few muscles
- neither brain or muscle could take it up during development, transport is very essential (case of boy in Berlin, couldn’t talk, hold head up and had very low IQ)
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