what is renin, it enters blood stream and cleaves the angiotenisin from the liver, to produce Ang2
ANG2 increases efferent arterioles, increases resistant to outflow of blood in the glomerulus a dn decrease resistance in afferent?
it also goes to the brain and causes you to be thirsty
ANG2 causes production of aldosterone in adrenal gland
decrease in volume = decrease in pressure = stimulation of cells in macule densa = increases enzyme that cleaves ANG to make ANG1 that goes to the lungs = ACE in the lungs converts ANG1 to ANG2 = acts on juxtaglomelular apparatus and acts on adrenal cortex to stimulate aldosterone release = act on nuclear receptors that controls expressure of Na+/K+ ATPase in these cells (pumping Na+ out of the filtrate and K+ enters)
get more hypotonic filtrate in the DCT
brings tonicity of filtrate to 50
they are the 2 hormones that work in combination to conserve water
pressure active transport of solutes, selective water permeability = how does this system work on its own
aldosterone controls pumps
vasopressin controls water permeability at the right spot at the right time
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