Brain morphogenic protein (BMP) is involved in dorsal ventral patterning in most animals and dictates gene expression. There are two antagonistic molecules that work to determine dorsal and ventral sides of an organism. In insects, DPP is located on the dorsal side and SOG is located on the ventral side. In the vertebrates, the dorsal side is chordin, and the ventral side has BMP4. In hemichordates, BMP is located on the dorsal side and anti-BMP like molecule is located on the ventral side. It makes them initially look like an insect. BMP is secreted from the top of the neural tube and Shh is secreted from the bottom of the neural tube (floor plate)
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