In addition to teaching and directing programs, Dr. Peterson has also published papers during her career. One paper that is particularly interesting is called Novel progesterone receptors: neural localization and possible functions. In this paper, she described research her lab conducted on rat forebrains. Their main purpose was to discover which receptors were most prominent in the brain, in an effort to decide which receptor she should focus to paper on. In order to do this, they used in-situ hybridization to map genes encoding receptors and their binding partners inside the rat’s forebrain. The findings are displayed with images of the x-ray film autoradiograms. Their information indicated that mPR (membrane progestin receptor) was not expressed significantly in the neuroendocrine area of the brain. On the other hand, PGRMC1, PGRMC2 and SERBP1 were expressed much more, and they were found in the hippocampus, cortical, and cerebral regions where functions controlled by progesterone happen. PGRMC stands for progesterone receptor membrane component, and SERBP is plasminogen activator inhibitor 1 RNA-binding protein. Ultimately, it was discovered that PGRMC1 was the most abundantly expressed gene in the results, so that is what they focused on in the review.
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