Bio Discussion on Gene editing and artificial selection in humans pt 2 Inability to control

Submitted by cbbailey on Wed, 02/13/2019 - 14:47

The second reason I believe that we shouldnt try to restrict this type of artificial selection is that we have very little way of stopping this artificial selection from occuring. In our modern day society, artificial selection already takes place at some levels, two examples being the mention of pregnacies being terminated due to certain genetic diseases being ddiscovered about the child as well as In the BBC article a couple specifically selected genes from a family with a long history of genetic deafness in order to have a deaf child.Even without the convervesial methods of gene editting, artificaill selection still occurs in our modern day world quite frequently, trying to limit the technology will only result in it being developed in different reguons of the world were it is accepted resulting in uus having less information and regulatory power over it to prevent it from being misused. Regardless if we allow this to procced, gene editing technology will continue to develop elsewhere and wilil eventually make its way back into society, potentially in an underground market which would allows us almost no power to enforces safty standards and safe practices. 

Methods (Draft 2)

Submitted by nalexandroum on Wed, 02/13/2019 - 13:49

To make the figure, I imported the four pictures into Pages. I clicked on each picture and dragged the corners to resize the pictures so that they each had a width of 3 inches, and also cropped each image to a width of 3 inches. I arranged the pictures in a square by putting the picture of the apple alone in the top left corner, the picture of the subject alone in the top right corner, the picture of the interaction in the bottom left corner, and the apple alone after the interaction in the bottom right corner. I dragged the cursor to select all four pictures at once, right-clicked and selected “Group” to make the four individual pictures into one single image. I inserted a text box in the lower right corner of each photo. In each text box I typed a label for each image: “a.”, “b.”, “c.”, “d.”. Each letter was lowercase and followed by a period, in 15pt Times New Roman font, and had a centered alignment. I arranged the letters such that the picture with the apple alone was  “a.”, the picture with the subject alone was “b.”, and the pictures with the interaction and the aftermath of the interaction were “c.” and “d.” respectively. I selected a text box, opened the “Format and Style Options” tab in the upper right corner of the document, then selected “Style”, and from the available options I picked the shape style with the black background and white text. I repeated this for each text box. I moved each label to be flush against the lower right corner of its respective picture, and resized the labels so that they each had a width of 0.60 inches and a height of 0.54 inches. I used the cursor to select the entire image, right-clicked and selected “Group” to integrate the labels into the final image. I went to File, “Export to” and selected “PDF”, setting the image quality to “Best”. I opened the .pdf file that was generated, and used the crop tool in the toolbox to select just the image and crop it. I saved the image—now without the white document background—and the figure was complete.

How far should gene-editing go?

Submitted by jhussaini on Wed, 02/13/2019 - 13:45

If it were up to me, I would allow genetic modifications only for disease prevention but I wouldn’t go a step further. To those who consider that unnatural, I would argue that humans have already defied natural evolution in many ways. According to the article “Pro and Con: Should Gene Editing Be Performed on Human Embryos?” we have prevented so many people from naturally falling sick and dying through advances in medicine such as antibiotics. Technology such as Crispr-Cas9 offers a more advanced way to prevent diseases, by editing DNA itself. In my opinion, gene-editing should be the go-to treatment for single gene disorders because it is tackling the issue straight from the source. Clinical trials for sickle cell anemia for example are already underway and have resulted in success with patients reported to show no more signs of the disease (according to the NYT article on sickle cell anemia).

However, I think there should be a limit to genetically modifying humans. Using gene-editing to select for desirable traits to increase reproductive fitness or make life easier for us in general can come with dire consequences. For one thing, genes are not always good or bad, but rather they can be a mix. Genes that cause people to be schizotypal or psychotic may confer advantages such as creativity and open-mindedness, according to the Time article “How Gene Editing Could Ruin Human Evolution.” The article also points out that influential people such as Carrie Fisher, David Foster Wallace and Kurt Cobain have made a positive impact on the world despite them all having psychiatric risks. Selecting for favorable traits is a complex process because it comes at the cost of another trait that could be beneficial. On a more personal note, artificially choosing genes to make a designer baby would take away from a person’s individuality. According to the wired article, “becoming a parent would turn into almost an intellectual exercise” or “project” that would focus on designing a baby rather than naturally giving birth to one. I think it’s important to appreciate our differences and flaws rather than trying to change them.

Structures for Respiration in Water

Submitted by ncarbone on Wed, 02/13/2019 - 12:28

Vertebrates and invertebrates have different structures that allow them to respire in water. Gills are a common structure that help an organism respire. Gills are respiratory sturctures that are fan like shapes with thin cuticular walls. Both vertebrates and invertebrates have gill like structures. Mostly all of the fish in the ocean are equipped with gills. As for invertebrates, many marine worms have gill like structures. As for other marine invertebrates, Echinoderms have thin walled gills that are extensions of body cavities. Sea cucumbers have respiratory trees and clams have gills that are aided by flagella. Some of these structures are much more efficeint than others. The more active the organism typically the more effiecnt the respiratory system is. Marine vertebrates typically have a set of structures that include an operculum, gill arches, filaments, and lamella. The operculum is the gill cover which provides protection. The lamella help with the diffusion of oxygen between water and blood.  

Circadian Rhythm and Mental Health

Submitted by alanhu on Wed, 02/13/2019 - 12:12

The CNS plays a role in the time we wake up. There are several genes that are involved in circadian rhythm. The retina in the eye is used to see how much light there is in the environment. The light is used to let the body know what time of day it was. Scientists believe that “night owls” are at a higher risk for mental diseases such as schizophrenia, yet there is no significance evidence that support this claim. A correlational study was conducted with the experiment participants to see whether they were a “morning or a evening person”. The body clock cycle is longer than 24 hours and the eyes are used to set the body on track with the 24 hour cycle. Though our bodies are influenced by our diets and what we do on the daily with artificial light. The light from screens affects the hormone level and core body temperatures on the sleep and waking patterning.

Using Inkscape - PP

Submitted by afeltrin on Wed, 02/13/2019 - 11:46

After taking and downloading the four photos onto my computer, I created a folder titled “Inkscape Methods.” I moved the four photos into that folder. I downloaded Inkscape and opened the application. I saved the project into the folder I created and titled the project as “Feltrin-original.” I imported the four photos at the same time. I locked the image properties at the top toolbar, resized each image, and cropped each image. I made sure each image was equally sized and comparable, paying careful attention and ensuring the two images involving my finger stroking along the stem of the leaf displayed the leaf at the same size. I set each photo’s width to 246mm. I aligned the four pictures so the photo of the quarter next to the leaf was in the upper left quadrant, the photo of the quarter next to my finger was in the upper right quadrant, the photo of my finger first touching the end of the plant closest to the main stem was in the lower left quadrant, and the photo of my finger touching the tip of the plant was in the lower right quadrant.

Using Inkscape

Submitted by afeltrin on Wed, 02/13/2019 - 10:53

After taking and downloading the four photos onto my computer, I created a folder titled “Inkscape Methods.” I moved the photos into that folder. I downloaded Inkscape and opened the application. I saved the project into the folder I created and titled the project as “Feltrin-original.” I imported the four photos at the same time. I locked the image properties, resized each image, and cropped each image. I made sure each image was equally sized, paying careful attention and ensuring the two images involving my finger stroking along the stem of the leaf displayed the leaf at the same size. I set each photo’s width to 246mm. I aligned the four pictures so the photo of the quarter next to the leaf was in the upper left quadrant, the photo of the quarter next to my finger was in the upper right quadrant, the photo of my finger first touching the end of the plant closest to the main stem was in the lower left quadrant, and the photo of my finger touching the tip of the plant was in the lower right quadrant.

Ecology application

Submitted by aprisby on Wed, 02/13/2019 - 10:22

I am the most driven by animal studies, whether that be animal behavior, the interactions between each other and the environment, and the evolution of different species. Personally I am keeping my options open after college in which area I work in, however I plan to work with animals in some aspect of research or rehabilitation. For research I am primarily interested in birds, especially raptor species, so would find it fascinating to study how birds are able to stand such extreme temperatures or how certain species are able to spot another member of its own species from a quarter of a mile way and know it is a female. Every part of this field relates to ecology because in order to understand these wild animals species, for instance why they migrate annually from location A to location B, we need to first understand the behavior or the animal itself and also the balance between the abiotic factors and the biotic factors. Perhaps it is migrating because there are not enough available resources in location A for a mother to nurse her young. We would need to understand what resources the animal needs in order to survive in a particular environment, as well as the climates it is able to withstand. Different environmental pressures may cause the individuals to move. And then this migration itself may also prove to be essential for other species to exist. It is a balance. However if some human activity disrupts this migration, is it essential we understand these interactions between species so that we may take the proper actions to counter it. I also feel that personally if I go into a wildlife rehabilitation field, I would need knowledge in ecology to be able to release a particular species into the correct environment, and also understand if the individual is fit to be released into its natural ecosystem.

 

LSD and Brain Signaling

Submitted by alanhu on Wed, 02/13/2019 - 09:23

There wasn’t much knowledge on what LSD does to the brain. Using an MRI, scientists observed how LSD can change the brain. Participants of the experiment were either given the drug or a placebo. Then a comparison between the two was made. Scientists examined the and compared the connectivity between the two brains. The CNS was looked at which includes the brain and the spinal cord. It was found that there was more information being sent between the thalamus to the posterior cingulate cortex. There was a decrease of information being sent to the temporal cortex. Depressive orders were found to have a high level of signaling between the thalamus and the temporal cortex. Since it was found that LSD can slow down the signaling to the temporal cortex, LSD might be considered as a medication for depressive disorders.

Gene Modelling

Submitted by ewinter on Wed, 02/13/2019 - 02:46

Two methods were used to arrive at our final predicted protein sequence for the RZW gene of Brachypodium distachyon.  The first method was an ab initio method.  The program FGENESH was used.  FGENESH analyzes genomic DNA and comes up with the most likely protein sequence, based on common characteristics of introns and exons.  For example, introns start with the nucleotides GT and end with AG. The program also recognizes the start codon, ATG, and the stop codons: TAG, TAA, and TGA.  The second method used a program called Phytozome. Phytozome is a DNA library, so it compares the genomic sequence of the RZW gene to known DNA sequences in B. distachyon.  It compares the genomic DNA to expressed sequence tags (ESTs), which are overlapping sequences derived from cDNA clones.  Because Phytozome compares the RZW gene to known cDNA sequences, its predicted protein sequence is more trustworthy than that of FGENESH.  

 

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