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Perfect Paragraph: SNP associated with hair curliness

Submitted by nalexandroum on Thu, 04/18/2019 - 15:25

SNPs that Promethease categorizes as  “not set” are ones that have no distinct “good” or “bad” repute. One of these identified in this Promethease report is rs11803731(A;A), a SNP  which is associated with hair curliness. The genotype that is homozygous for the “T” allele is associated with curlier hair, whereas the homozygous “A” genotype is associated with straighter hair. This individual has the homozygous “A” genotype, which means that they likely have hair that is less curly and on the straighter side. rs11803731 is found on the Trichohyalin (TCHH) gene which, according to a study of Australians of European ancestry, accounts for an estimated 6% of the variance in hair morphology. The TCHH gene codes for trichohyalin, a protein that is highly expressed in hair follicles and the innermost layer of the hair shaft, as well as being detected in other places such as areas of the epidermis, in the hard palate, and in the nail matrix. Trichohyalin links the heads and tails of keratin chains and is therefore involved in the cross-linking of keratin intermediate filaments, overall contributing to the mechanical strength of the inner sheath of root follicles and other keratinized epithelial tissues.

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Comments

Write out SNP then abrbreviate it, unless this is a paragraph written after it is already written out.

I would split up the sentence "The TCHH gene codes for...etc." in two, it's very long as of now. You could put a period after "hair shaft" and start the next sentence with "This protein is also detected in areas of the epidermis, etc."

"rs11803731 is found on the Trichohyalin (TCHH) gene which, according to a study of Australians of European ancestry, accounts for an estimated 6% of the variance in hair morphology." To avoid distrupting the flow of the sentence, perhaps begin with "According to a study of Australians..."