Dopamine and Music

Dopamine is a neurotransmitter involved in pleasure, reward, and motivation. In this study, researchers manipulated dopaminergic synaptic availability through the use of three substances: levodopa, risperidone, and lactose. Levodopa is a dopamine precursor that increases dopaminergic availability. Risperidone is a dopamine antagonist that reduces dopamine signaling. Lactose is a placebo that does not affect dopaminergic neurons. The researchers used electrodermal activity to measure changes in pleasure and reward while listening to music. These songs included the participants’ favorites as well as ten other singles. Participants rated songs in real time in terms of pleasure and monetary value (how much money they would pay for the song). Results exhibited a causal link between levels of dopamine caused by the drugs given and pleasure as well as motivation. Participants given levodopa gave higher emotional response ratings than compared to the lactose placebo and were more likely to spend money on the music they were listening to. Those given risperidone were unable to experience chills, an emotional pleasure response, and gave lower emotional response ratings compared to the placebo. They were also less willing to spend money on the music, indicating a weaker motivation to listen again.

https://neurosciencenews.com/dopamine-music-10628/