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EGFR/KRAS Perfect Paragraph

Submitted by sditelberg on Fri, 02/08/2019 - 00:07

The EGFR/KRAS pathway, commonly mutated in pancreatic adenocarcinoma, is a promising area of focus for targeted tumor treatment. A point mutation in codon 12 of the KRAS oncogene is nearly ubiquitious to all pancreatic adenocarcinomas. Targeted therapies would need to specifically focus on this mutation in the cancerous cells without damaging the growth pathway in normal, healthy cells. A possible therapy that may accomplish this goal includes a microRNA with a complementary sequence for the point mutation, which would allow it to bind to only cancerous cells. After binding, expression of the EGFR/KRAS pathway would be blocked by either degradation of the mRNA or by blocking translation through a ribosome. A challenge that remains is introducing this interfering RNA into cancerous cells. Liposomes may serve as useful areas for transport inside the cell after binding to cancer-specific antigens on the surface.

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Comments

klaflamme

Fri, 02/08/2019 - 11:51

Awesome opening and closing sentences. This paragraph is formal, scientific, and well written. However, I would change a the wording of some things. "Targeted therapies would need to specifically focus on..." I don't think you need to use the word 'specifically' here, the sentence would sound better without it. "A possible therapy that may accomplish..." Perhaps here, you could introduce the sentence with what the therapy is called, "XYZ therpay, a new therapy that may accomplish this goal, ..." "A challenge that remains..." I think here you should say "However, it is unknown how to introduce this..." 

I think you have a strong introduction sentence that allows the reader to know exactly what the paragraph will entail as well as very well written and strcutured sentences that follow. If I were to suggest anything you could include the current status of the treatment today or when the treatment was introduced so that the reader has a context if this is a relatively new advancement or something they are still working on today. 

One suggestion is to elaborate on how this therapy would be done, its procedure, in order to shed light on some of the challenges that you mention later associated with the treatment.