Cancer research is so challenging because there are SO many different influences. Many things we encounter in our lives, such as radiation, technology, red meat, smoking, etc., are said to cause cancer, yet we still expose ourselves to those things. Clearly we can't avoid everything that is said to cause cancer, but I find it interesting that only 1% of cancers are found to be hereditary. In cancer, I would expect to see p53 mutations or there could be many other signaling/survival/etc pathways influenced in cancers. For example, we talked about the Bcr-AbI mutation that leads to a certain type of leukemia.