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Mechanisms of Diabetes Pt.1 (Perfect Paragraph)

Submitted by ncarbone on Fri, 01/25/2019 - 15:27

Mechanisms of Diabetes

Diabetes can lead to major health complications such as nerve damage, kidney damage, and cardiovascular disease. The three mechanisms which influence these diabetic complications are: blood pressure, glucose control, and lipid control.

Nephropathy, a disease/damage to the kidneys, is characterized by the development of proteinuria and a decline in glomerular filtration rate. High glucose levels and high blood pressure are the main causes of nephropathy. The high levels of glucose in the blood cause an increase in glucose reabsorption which then leads to both hyperfiltration and increased intraglomerular. This extra pressure on nephrons over time weakens their ability to filter, ultimately leading to kidney damage and leakage of proteins into the urine.

Retinopathy, described as lesions within the retina, is also caused by high blood pressure and poor glycemic control. Hyperglycemia causes changes to the blood vessels in the retina by damaging or killing pericyte cells (The cells that line blood vessels and help regulate blood flow) which then alters the blood-retinal barrier and vascular permeability. Damage to the retinal blood vessels eventually results in ischemia. In response to ischemia, neovascularization takes place which is the formation of new blood vessels. The new fragile blood vessels that grow in the retina are prone to leaking blood into the back of the eye. The leaking of the fluid into the macula (Area responsible for clear central vision) causes the macula to swell, thus leading to vision loss.

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Comments

klaflamme

Fri, 01/25/2019 - 15:41

  • I don't think you need to include a colon in between "...these diabetic complications are blood pressure, glucose control, and lipid control".
  • "a disease/damage to the kidneys" this sounds a little awkward. Maybe say "Nephropathy is a disease to the kidneys that is characterized by..." or if it is a type of damage say that (I am unsure on the specifics of this)
  • "This extra pressure on nephrons over time" I think you can cut out the "over time" it sounds like a filler
  • I would say try not to make every description of something in this structure;"Nephropathy. a disease/damage to the kidneys, is characterized by" "Retinopathy, described as ..., is ....", try to switch it up.

This looks like more than one paragraph. For the "perfect paragraph" activity, please submit a single (perfect) paragraph.

angelinamart

Thu, 01/31/2019 - 18:43

I do not think you should capitalize when you write in ( ). Otherwise, I think your writing was well-explained but as Professor Brewer said, I think you need to write this in one paragraph.