All cellular RNAs are synthesized from DNA templates through the process of transcription. Transcription is in many ways similar to the process of replication, but a fundamental difference relates to the length of the template used. In replication, all the nucleotides in the DNA molecule are copied, but in transcription, only parts of the DNA molecule are transcribed into RNA. Because not all gene products are needed at the same time or in the same cell, the constant transcription of all of a cell’s genes would be highly inefficient. Furthermore, much of the DNA does not encode any functional product, and transcription of such sequences would be pointless. Transcription is, in fact, a highly selective process: individual genes are transcribed only as their products are needed. However, this selectivity imposes a fundamental problem on the cell: how to recognize individual genes and transcribe them at the proper time and place.
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