Scientists had found that long term use of opioid medications can cause a change in hormone levels. 65% of males that use opioid medications long term started to develop hypogonadism. Hypogonadism is a condition that causes erectile dysfunction and infertility. It can also cause a loss in muscle mass, hair loss and eventually development of breasts. Another condition is hypocortisolism, low levels of cortisol. Cortisol is responsible for metabolism and immune response. Having low cortisol levels can cuase fatigue, weight loss and mood changes.
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