Therapeutic Intervention for Metastasis

One possible area of therapeutic intervention suggested by McAllister and Weinberg would be inhibition of the intercellular signaling that ultimately leads to metastasis.  Small molecule inhibitors or neutralizing antibodies are what McAllister and Weinberg propose as options.  The authors mention that instigation into the clinical use of haematopoietic growth factors such as G-CSF, which is known to recruit pro-tumorigenic bone marrow cells, is ongoing.  Thus far, the clinical justification for this type of treatment seems dubious due to the pro-tumorigenic role of G-CSF.  Anti-angiogenic therapies have been improved and continue to be researched.