Triglycerides are also proposed to have an impact on the development of neuropathy. It has been hypothesized and studied that triglycerides and obesity correlate with diabetic neuropathy independent of glucose control. Smith and Singleton found that obesity and triglycerides were related to small axon loss whereas hyperglycemia was related to large fiber loss indicating that hypertriglyceridemia and obesity have an independent effect on peripheral neuropathy. Wiggin et al performed a double-blind placebo clinical trial which showed a correlation between elevated triglycerides and loss of sural nerve myelinated fiber density in diabetics with mild to moderate neuropathy.
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