Today in biochemistry we learned about the charges of amino acids and the effect that those charges have on structure. Acidic and basic amino acids have R-groups that can ionize. The individual R-groups have different pKa values at which they deprotonate. Each peptide chain also has an N-terminus at the front of the chain and C-terminus at the end which are cabale of ionizing. Certain amino acids cannot be next to each other on peptide chains due to opposing charges. When two positively or two negatively amino acids are next to each other, they will repel each other. This greatly effects the structure of the protien. This is a problem because protein structure determines its function. Therefore, if there are structural issues then this will effect the overall function of the protien.
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