Week2 Draft2

In the research done by Laurent Debarbieux et al on treating P. aeruginosa lung infections through bacteriophages, the authors used mice as their test subjects, as well as different primary colonization and chronic strains of the bacteria P. aeruginosa, and the virus they called PAK-P1. Even though the research revealed bacteriophages' effectiveness in treatment in vitro, the researchers were questioning its effectiveness in vivo. Through this article, they revealed their research on the effectiveness of treatment of bacterial infections with the bacteriophages. Their hypothesis: if bacteriophages are effective in attacking only the bacteria, the bacteriophages will significantly reduce the bacteria in the victims and thus saving them. The dependent variable was thus the survival of the test subjects, the mice, and the independent variable is the amount of bacteriophages. The controls were infected mice not treated with any bacteriophages. Experimental evidence reveals that timing and dosage of bacteriophages mattered in saving the lives of the mice. This is therefore important in possible treatment with humans.