Treatment Idea for HGSOC

In order to treat both pathways, we are planning to use elements of CRISPR gene editing techniques.  In order to target the HGSOC cells, two hallmarks of the cancer have been identified: CA-125 and MAGE-A10.  One idea we have is to insert mRNA for the BH3 protein into cancerous cells. The cell could then translate this pro-apoptotic protein.  For the cell proliferation pathway, c-Myc is likely amplified in part due to the extremely common loss of function mutations in p53 (tumor suppressor).  If we could inject mRNA coding for p21 into the cells, then the cell would transcribe p21, the CDK inhibitor that promotes apoptosis, that normal p53 acts as a transcription factor for.  We could also use CRISPR to edit the genome itself, possible looking at promoter/enhancer regions for the c-Myc gene, or just cutting the gene out entirely. More research is needed into how to target this therapy, because once that is sorted out, we view this mechanism as a pretty comprehensive solution to many cancers.