Liposomal Therapy Additions

It is crucial for the selected antibodies on the liposome to work in conjunction with each other to bind to only pancreatic adenocarcinoma tumor cells. Although their respective antigens are overexpressed in tumors, they may be still present in lower concentrations in healthy cells. Therefore, the liposome would be best engineered for the antibodies to only bind to antigens when the displayed antigens are present in high enough concentrations. This threshold could be determined through titration experiments until the effective concentrations of antigens are achieved. The use of liposomal therapy also appeals to the researchers due to its adaptability and lower toxicity. In a study involving paclitaxel, the liposomal form induced fewer cardiovascular and hematologic complications than the standard form (Huang et al. 2018). Encapsulation efficiency has also been measured by injection of a doxorubicin liposomal solution into liquid chromatography (Yamamoto et al. 2018). The researchers would like to use this method to further assess liposomal drug delivery.