Cohesin in cell division
Cohesin is a protein that holds chromatids together. Cohesin is established in cell division during S phase and persists through G2 phase and early mitosis. In anaphase, cohesin along the entire length of the chromosome is broken down by an enzyme called separase, allowing the sister chromatids to separate. It is important that separase functions properly so that both the mother cell and daughter cell each get the appropriate number of chromosomes. Forms of cohesin differ between mitosis and meiosis. In meiosis anaphase I, cohesin along the chromosome arms is broken, allowing the two homologs to separate, and cohesin at the centromere is protected by a protein called shugoshin in order to keep the now separated chromosomes to stay together at their respective centromere.