SH3 and SH2 domains play a large role in many signal pathways. It is a binding site for proteins with phosphorylated tyrosine. By the name auto inhibition, I would assume the protein itself is able to inactivate itself. I am curious to know how this system works exactly, though. I wonder if the protein receives a signal? These are common pathways that was addressed in class. There are 3 proteins that are needed for the activation of this pathway. If there is a mutation that influences the function of one of these proteins, the enter pathway is affected. Is there a way for the pathway to compensate for a mutation in one of these proteins? If so, how does that work? Grb2 is a growth factor receptor-bound protein. It is a big player is many signal transduction pathways and cell communication.
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