RNMTL1 draft

RNMTL1 is a protein that methylates ribosomal RNA. When there is a RNMTL1 deficiency in the body, it leads to the failure of modifying nucleotides of the 16S rRNA loop. More specificially, the A-loop cannot form properly. This causes peptide bonds to not form correctly and ultimately affect protein synthesis as well. Additionally, mitochondrial translation cannot be carried out as normal because the large subunit of the mitochondrial ribosome does not form properly when the 16S rRNA loop is not modified. RNMTL1 is also known as MRM3 and works with MRM1 and MRM2 for methylating mitochondria rRNA. Low MRM2 levels directly correlates with low U1369 modification while low RNMTL1 levels correlates with decreased G1370 modification. The modification of these nucleotides is what helps the subunits needed for mitochondrial translation to form properly. In embryos with a deficiency of RNMTL1, I would expect to see poor development in sources that need lots of energy, such as the heart and skeletal muscle. I expect this because the mitochondria is known for providing the body with ATP and energy. If part of the mitochondria is not translating properly, then places that need high energy will be greatly affected. I would also expect to see slower growth in embryos without RNMTL1 than cells with RNMTL1.