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notes of thin filaments

Submitted by msalvucci on Wed, 11/14/2018 - 18:45

Once calcium floods the cell, it attaches to troponin. Troponin, a regulatory protein on the thin filament, changes shape when bound to calcium. This shape conformation causes the tropomyosin protein to shift away from the actin binding site on the thin filament strands. The binding sites of actin must be exposed for contraction to occur. ATP bound-myosin on the thick filament can then bind itself to the actin binding site and pull the thin filament towards the center of the sarcomere. Following this movement, another ATP binds to myosin, and myosin uses the ATP to release from the actin and cock itself. The myosin gets ready to bind another actin if and when it is exposed. This process creates the contraction of a skeletal muscle

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