Metabolic coupling is the process of using energy released from an exergonic pathway to provide energy needed for an endergonic pathway. The main goal of metabolic coupling is to end up with a negative change in free energy (delta G). A negative change in free energy indicates a spontaneous reaction. Metabolic coupling can exist in three forms: between biochemical pathways, within biochemical pathways and within chemical reactions. Energy transfer within metabolic pathways involves the removal of phosphate groups through hydrolysis, thus resulting in a large negative free energy value. The amount of free energy available in the bond is called the phosphoryl group transfer potential. Phosphorylation is the reverse reaction of adding phosphate groups through the input of energy (ATP).
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