Guanine protein coupled reactions (GPCR's) are a type of G-protein linked receptors that detect molecule outside the cell and cause a cell response. Initially, the guanine protein is made up of three subunits, an alpha, beta, and gamma subunit. When a ligand attaches on the outside of the transmembrane protein a conformational change occurs and the GPCR can activate an associated G-protein by exchanging a GDP bound to the alpha subunit with a GTP. When the alpha subunit is phosphorylated it dissociates from the beta and gamma subunits, which stay together. Both sections, the alpha subunit and the beta-gamma subunit complex, are now able to act on effectors that the are proper for the received signal. This continues until the alpha subunit is dephosphorylated. When this happens, all three subunits are rejoined and the GPCR returns to a resting state.
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Each week, post your own Perfect Paragraph and comment on three Perfect Paragraphs. Suggest improvements. Don't just say "Looks good."
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Comments
Proof read
While reading this i noticed a few spelling mistakes. For example, the third to last sentences says "...on effectors that the are proper for..." A quick read through would have caught this. Otherwise, you did a really good job concisely describing the GCPR pathway!
You should act as if you are
You should act as if you are writing this for the general population, who may not know what GDP or GTP are. They may need some explaination or at the very least an introduction on what the letters stand for as you did for GPCR.