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gluconeogenesis pp

Submitted by msalvucci on Thu, 11/29/2018 - 19:46

Glycolysis and gluconeogenesis are two glycolytic pathways involving the synthesis and degradation of pyruvate from glucose. Although these reactions look like the opposite of each other, gluconeogenesis actually bypasses three pathways involved in glycolysis. Three irreversible reactions including the enzymes hexokinase, PFK-1, and pyruvate kinase must be bypassed due to their change in free energy. The changes in free energy for these pathways are -33 kJ/mol, -22.2 kJ/mol and -33.2 kJ/mol respectively. When a reaction has a change in free energy that is 0 or close to 0, it is easy to reverse and therefore is used in the process of gluconeogenesis. Being that the changes in free energy for these three pathways in glycolysis have such high negative values, gluconeogenesis must find a way around these reactions in order to degrade pyruvate. Therefore, the reaction uses different enzymes for these three pathways in order to complete the degradation of pyruvate when necessary.



I like the amount of detail, the only thing I would look over is the punctuation, you're missing a few commas and periods. 

Your paragraph does a good job of going into specifics, but the flow could use a little improvement. Also, I would maybe try to make of more apparent conclusion sentence. Other than that the paragraph is well written.