genetics draft

I found it interesting that parts of the plasmids often end up integrated in the original genome as well as that immune responses sometimes compete with the gene editing and influences its efficiency and effectiveness. While clearly with further research and understanding of the CRISPR-Cas9 pathway and function as well as its transfer to target cells can help limit this, it makes me question gene editing. I feel like our genome is our genome for a reason and when we mess with that, it messes with the function of our DNA, cells, and our entire system. Additionally, there is still a decent amount of complications and even patient death with this process and I feel like it is very difficult to have volunteers for studies with this due to the risk involved.