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Comments for assignment 2

Submitted by cdkelly on Tue, 10/02/2018 - 23:54

When a signal binds to a receptor, it undergoes a conformational change that leads to the desired effect on the cell it is attached to. Based on what we have learned about protein folding and the chemical interactions at the different levels of structure, I believe that these conformational changes that happen to receptors are similar. For instance, if the ligand that binds to a receptor contains a lot of negatively charged amino acid residues, it could repel certain parts of the polypeptide comprising the receptor. This would cause it to physically shift and take on a new conformation.

I wonder if the number of signals that meet at an integrator can vary? If there was say ten signals bound to an integrator versus 20, would there be a more rapid response? Or maybe there is a threshold that needs to be reached in order for the integrators to perform its function?

An example of this is how epinephrine travels through the blood and binds to a number of different cells in the body. For instance, the resulting signal cascade and effect epinephrine has on cardiac tissue is much different than epithelial tissue. Because of this, epinephrine (adrenaline) has a huge variety of different functions within the body.

Something that is interesting about receptor binding sites and their corresponding ligand binding partners is that shape plays a massive role. Similar to how a block fits into hole on a child's toy, each receptor has a specific binding site shape that corresponds with the signal that is meant to bind it. This ensures that molecules that fit into the binding site are the only thing that can bind. This goes hand-in-hand with ways that drugs interact within the body. Biochemists and pharmacologists design drugs to mock that shape of the binding partner of a given receptor to elicit a specific response within the cell and consequently the body.

I'm also a little confused by this concept, but I do know that tyrosine kinases are fundamental molecules that perform signaling transduction in a massive number of cellular pathways. It has the ability to transfer phosphate molecules, which are crucial units of energy within the cell. But I think that SH2 and SH3 are able to modify the activity of a receptor and consequently result in a more specific signaling cascade after something like a growth factor binds.

 

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