It's interesting that the centrosome cycle can simultaneously occur with the other processes of replication. When I think about all of these different processes, it becomes difficult to picture all of these different proteins acting simultaneously with one another to complete massively complex procedures. Also, this is happening across millions of cells at the same time and the overall orchestration is hard to picture.
These processes must occur in a sequential order. If they somehow began too early or in the wrong order, the consequences within the cell would be devastating. For example, if M-phase began before S-phase was complete, the resulting daughter cells would be deprived of a number of chromosomes and become destined for cell-death. Perhaps overregulation of specific cyclins could lead to something like this.
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