Since scientists still don’t know much about the specific proteins involved with this process, it is hard to give a straight answer. I would assume that the binding site would be the same or at least fairly similar on the different proteins since they all bind to M-Cdk. I never really thought about the fact that protein degradation/proteolysis would be necessary for sister-chromatid separation. However, it makes a lot of sense. If the proteins keeping the chromatids together were still present, it would be much more challenging or even impossible to separate the chromatids. The kinetochore plays a huge role in mitosis, especially sister chromatid separation. While kinetochore sends a signal if the spindle is not properly attached, mutations must occur occasionally. This would most likely lead to an extra chromosome or lack of chromosome in a cell. I wonder if there are any other consequences of a lack of negative signal.
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