While they seem nearly identical, they are actually quite different. If you tried to place the L amino acid on top of the D amino acid, it would be impossible for them to line up the same way. This leads to their interaction with other molecules to be different from one another. Online I found that it is still not fully known why D amino acids are so rare, but found it is manly because L amino acids tend to be more successful in nature for some reason. A cross link is a bond that links one polymer chain to another. Examples of this can be covalent bonds or ionic bonds. Here, with proteins, it would be the peptide bonds. A cross link is a bond that links one polymer chain to another. Examples of this can be covalent bonds or ionic bonds. Here, with proteins, it would be the peptide bonds. I find it surprising yet interesting that ion pairs between N and C groups as well as strong disulfide bonds and hydrogen bonding don't contribute much to the stability of a protein. Disulfide bonds are one of the strongest bonds so I would think that bonding would help stabilize the protein. However, structures and ions such as zinc are more important with helping with the stability of a protein.
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