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summary of an article and history of sickle cell anemia

Submitted by ziweiwang on Tue, 09/10/2019 - 20:15

The paper that I read is the Effect of Acute exercise on RBC deformability and RBC Nitric Oxide Synthase Signalling Pathway in young sickle cell anemia patients. The goal of the research was to see if exercise negatively affected patients with sickle cell anemia. The key finding of the study was that there was a slight decrease in red blood cell deformability in children who have sickle cell anemia. Red Blood Cell deformability is the red blood cell’s ability to bend when squeezing through the blood vessels. However, the paper ultimately concludes that even though the RBC deformability in children in sickle blood cells was lower compared to children without sickle cell anemia, overall, exercise does not negatively impact RBC deformability in children with sickle cell anemia. The impact of the paper in sickle cell research is that it rules out the role of exercise in the factors that worsen the symptoms of sickle cell anemia. 

 

Grau, M et al Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signaling pathway in young sickle cell anemia patients, Scientific Reports. 9, 2045-2322 (2019)

 
 

1910 is considered to be the year that the disease was discovered. James B Herrick noticed that in the blood of his patients that their blood cells were in the shape of a sickle, and as a result named the disease like sickle cell anemia. However, the hereditary nature of sickle cell anemia was only found out since 1949 when it was demonstrated by Dr. James Neel. Linus Pauling then discovered that the disease was due to a structural change in the hemoglobin in 1951.

 

leaf observation

Submitted by ziweiwang on Fri, 09/06/2019 - 15:40

The stem of the leaf is reddish-pink with the darkest color at the point where three of the leaves join together. The color is similar to rhubarb almost where the color is vastly more blue-tinted rather than orange-tinted, more berry tone rather than coral tones. Looking at the end of the stem, the outside of the stem is pink the inside is green. The inside is also fibrous, with uneven strands, giving the impression that the leaf is ripped apart from the tree rather than cut with a scissor or fallen from the tree naturally. The fibrous inside is slightly glossy that gives an impression of being wet or at least there used to be some liquid on the stem. it's the glossiness where a sugary viscous drink is spilled over on a surface and after it has been dried, there are sticky spots that when the light hits it just rights it becomes shiny as though there is a waxy varnish on the surface.  At the end of the stem, there are some sort of white waxy substance that is not present in any of the other parts of the stem

leaf observation

Submitted by ziweiwang on Fri, 09/06/2019 - 15:37

The professor gave us a leaf and told us to write about it for 15 minutes. The bag that the teacher took the leaf out from had a napkin. I wonder what that is for. the bag was also kind of foggy. is it to keep the leaf from wilting? as for the lave that was given to me, there are three leaves on the small structure. a large one and two comparatively smaller one on either side. two of the leaves, the big one and one of the smaller ones have brown spots on the side of it. it spirals from the stem of the leaf to the other end of the leaf. It looks kind of like a path that a small bug would eat through except that there are no big empty spots where is only brown spots that becomes lighter at some places and darker in others. the feel of the leaf is mostly dry in the feeling that while it has been a while since someone has picked off the leaf, it isn't dessecated that if some pressure is applied and the leaf is bent slightly the leaf would snap off in a billion piece. on the back of the leaf, the brown spots are slightly lighter in most places, although there are some part of the leaf that is just as darker as the front of the leaf, there are less of it, and the darker patterns are more circular, giving off the appearance of a spots that have been connected by lighter brown rather than  a lighter brown crawling across the leaf, getting larger and darker as it goes on. how large the spots do not seem to affect the color of the spots. there are areas where the spot is quite large but the color is not as dark as some of the smaller area that is near the end of the leaf. 

the stem of the leaf is reddish-pink with the darkest color at the point where three of the leaves join together. the color there is similar to rhubarb almost where the color is vastly more blue-tinted rather than orange-tinted. looking at the end of the stem, the leaf appears to almost be ripped apart from the tree because while the outside of the stem is pink the inside is green. the inside is also fibrous, with uneven strands, giving the impression that the leaf is ripped apart from the tree rather than cut with a scissor or fallen from the tree naturally. The fibrous inside is slightly glossy that gives an impression of being wet or at least there used to be some liquid on the stem. it's the glossiness where a sugary viscous drink is spilled over ona surface and after it has been dried, there are sticky spots that when the light hits it just rights it becomes shiny as though there is a waxy varnish on the surface.  the stem's color fades at the middle of the leaf, it fades not in a rainbow-like way where the color goes from red to orange to yellow to green, but from red to pink to yellow. 

The leaf is also not completely flat. when the stem is placed parallel to the desk, the largest leaf floats upwards and one of the smaller leaves ( the one with brown spots) have a noticeable slant facing the larger leaf. ok, so apparently the leaf is a compound leaf and what I've been calling leaf is called a leaflet. anyway, the entire leaf is 5.5 cm from stem to leaf. the stem is 1.5cm, which is surprising because I thought that it would be longer. across the leaf from the tip of one of the smaller leaf to the other is about 5 cm, making the leaf sort of square-shaped. and pleasing the eye.  compared to others, my leaf is darker than the one that professor is holding up and lighter than the leaf that the person next to me has. the leaflet is 3.2cm, 2.4cm and 2.6 cm, which is also surprising because I thought that the 2.6 cm one would be larger. Since that leaf has a gradient of lighter green and a darker green, the color may have influenced me to think that the 2.6 cm leaf was larger. 

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